Toward a research-based pharmaceutical company tackling uncharted targets
Kotobuki Pharmaceutical Co., Ltd. is a research-driven pharmaceutical company focused on the creation of innovative new drugs. Guided by the philosophy of “turning targets that have not yet become drugs into medicines,” we tackle disease areas that existing treatments have been unable to address, aiming to create first-in-class drugs with novel mechanisms of action.
Our small team size allows us to focus deeply on science. We closely integrate chemistry, pharmacology, formulation, and analytical technologies to advance drug discovery research that captures drug efficacy at the molecular level. Through collaborative research with academic institutions and pharmaceutical companies both in Japan and abroad, we continue to refine our unique drug discovery engine.
Drug Discovery Research
Exploring New Mechanisms of Action
We are pursuing drug discovery that targets the underlying mechanisms of disease rather than simply modifying known targets.
- Precision organic chemistry based on small-molecule drug discovery
- Pharmacology and biology
- Computational science and structural analysis
- Molecular-level analysis of mechanisms of action
By integrating these disciplines, we drive a seamless process from target identification to lead optimization and efficacy and safety evaluation. By thoroughly elucidating “why” a drug works, we aim to create pharmaceuticals that deliver true value in clinical practice.
Research and Development Structure
Research Institute / RI Research Facility
We have established a state-of-the-art research infrastructure to support drug discovery research.
- Research Institute : Close collaboration among organic synthesis, pharmacological evaluation, analytical chemistry, and formulation research
- RI (Radioisotope) Research Facility : Advanced pharmacokinetic and distribution analysis
We have created an environment where researchers can engage in discussions across disciplinary boundaries, enabling rapid decision-making and hypothesis testing.
Core Technologies Supporting Drug Discovery
The Integration of Chemistry, Analysis, and Pharmacology
For many years, we have continued to invest in cutting-edge equipment and analytical technologies to support drug discovery research.
In addition to a suite of advanced analytical instruments, including NMR, MS, LC/MS/MS, and HPLC, we utilize HTS (high-throughput screening), structural analysis, and drug design technologies.
Furthermore, by comprehensively evaluating efficacy, safety, and physical properties from the early stages of drug discovery, we aim to increase the probability of successful development.
Major Research Facilities
- NMR
- MS / LC-MS/MS
- HPLC
- HTS (High-Throughput Screening)
- Microwave Synthesis System
- Parallel Synthesis System
- X-ray Powder Diffractometer
- Thermal Analyzer
- Dissolution Tester
RI Research Facilities We comprehensively evaluate efficacy, safety, and physical properties from the early stages of drug discovery to improve the probability of successful development.
Formulation Research
Formulation Technology Born from the Patient’s Perspective
We place equal emphasis on drug discovery and on developing formulations that are easy for patients to take.
Leveraging formulation technologies we have cultivated over many years—such as rapid-disintegration formulations and stabilization techniques—we are advancing the development of formulations that achieve a high level of balance between efficacy, safety, and patient compliance.
Rather than merely changing the dosage form, we contribute to improving patients’ quality of life through “formulation design that maximizes the value of pharmaceuticals.”
Our Commitment to Quality
Manufacturing and Quality Assurance Systems Supporting Drug Discovery Quality
Pharmaceuticals must meet the highest standards of quality and ensure a stable supply.
We have established a manufacturing and quality assurance system that complies with strict GMP standards, and we practice a comprehensive quality management approach that incorporates quality design from the research and development stage.
In addition, we have introduced energy-efficient equipment and environmentally conscious designs, and we are committed to sustainable pharmaceutical development.
Generic Drugs Business
Bringing technologies developed through new drug research to the clinical setting
Leveraging the quality, formulation, and analytical technologies we have developed through our new drug research, we are also actively engaged in the generic drug business.
We prioritize stable supply, quality, and information sharing, and are committed to developing products that earn the trust of the medical community.
Through the technological foundation we have honed in our drug discovery research, we are also committed to contributing to the sustainability of healthcare.
Bringing innovative new drugs from Japan to the world
We are a company that competes on the strength of science, not size.
We tackle unmet medical needs and pioneer new mechanisms of action. And we bring innovative Japanese-developed medicines to the world.
We remain fully committed to drug discovery research.
