Kotobuki pharmaceutical Co., Ltd.

Timeline of Kotobuki Products;

Since our founding, we have built our business on herbal medicines that utilize local resources. As times have changed, we have expanded our scope to include chemically synthesized pharmaceuticals and R&D-driven products, consistently providing the medicines society needs.
The herbal preparations highlighted in green represent the origins that supported our company in its early days and symbolize our spirit of manufacturing rooted in the local community.
On the other hand, our chemically synthesized pharmaceuticals and R&D-driven products are a product line created based on the R&D capabilities and formulation technologies cultivated since our second founding, reflecting our journey of challenge and evolution.
Our history of product development, accumulated over more than 75 years, embodies our commitment to always prioritizing the health of our patients and the needs of the medical community.
Moving forward, we will continue to provide new value to healthcare by fusing tradition with innovation, leveraging our unique technologies and R&D capabilities.


Green text: Herbal preparations that supported our early years (products utilizing local resources)
Black text: Chemically synthesized pharmaceuticals and R&D-driven products

Year of releaseProduct Name
1949APRICOT KERNEL WATER, POTASH SOAP, CRESOL SOAP LIQUID, SIMPLE SYRUP, WHEAT GERM
1951SENEGA SYRUP, SCOPOLIA EXTRACT, SCOPOLIA EXTRACT DISPERSION, BERBERINE, ZINC OXIDE OIL
1954SERPEN
1956RUTIN(Japan/Europe/USA), GREENFILL
1957TOMISERTIN
1958PEPPER EXTRACT
1960RECERPIN POWDER
196110 TIMES DISPERSION NARCOTINE, DIHYDROCODEINE PHOSPHATE
1962DIBETON, KOREAN CARROT EXTRACT
1963ENLES TAB., SAPOMAC, CODEINE
1964TRIAMTERENE, KUKO EXTRACT, DIUTEREN TAB., KIZORON TAB.
1965NICOHEXAN TAB.
1966PROTEFIRIN
1967CLOFIBRATE, PROTOPORPHYRIN DISODIUM, MARZULENE-S GRANULES, DIUTEREN GRAN., MULASE TAB.
1968SPADELATE CAP., ADETIDE ENTERIC COATED TAB., DIBETON S TAB. (ENTERIC COATED)
1969BINOGRAC CAP.
1970WAXNATE
1971SARTIRON  TAB., HOMOCURO CIKURIJINN TAB., TIRENON TAB., MECLOFENOXATE HYDROCHLORIDE
1972IGURARIN CAP., TRIMEPERAD TAB., HORMITOL TAB., PROTPORT TAB., MECLOSERT TAB., BINOGRAC 500, CLOFIBRIC ACID ALUMINIUM SALT
1973WATER-SOLUBLE AZULENE, TRIMETAZIDINE
1974THIAMPHENICOL
1976SPADERIZINE CAP., TOLPERISONE HYDROCHLORIDE
1978STEROZINE POWDER
1979STEROZINE CAP., BESNOLINE GRAN., SKAJIL CAP
1980GEFARNATE, ALPRENOLOL HYDROCHLORIDE
1981ALCLOFENAC, SOBULALINE TAB., STEROZINE GRAN., KOTOZOLE SOLUTION/CREAM/VAGINAL TAB.
1982NERABOLE CAP., LACOBILE TAB., BESNOLINE F TAB., RASCARJINE CAP., MULASE S GLAN., LET-LIT TAB., CEFALEXIN DRY SYRUP, SKAJILOL CAP.
1983SKAJILOL 50 CAP.
1984NEUMETHYCOLE TAB., RASCARJINE TAB., CIROCIPIDO GLAN., KOTOMOL TAB.
1986CODEINE PHOSPHATE 100 TIMES DISPERSION「KOTOBUKI」
1987MUIRODINE FINE GRAN., SUMIDORUMIN TAB.
1990ZATOTITEN CAP., PADOPARINE TAB., MYONABASE TAB.(Japan/Korea), MARZULENE-S GRANULES(China/Korea)
1992KOTOBULOL TAB., CAGUDALIN CAP., CAGUDALIN FINE GRAN., CAMRITON 0.25mg TAB.
1996ANBUJILE TAB., PORATILE 2mg/3mg TAB.
1998LOXIPRONAL TAB.
2000AZULOXA GRANULES 2.5%, KORTRYTHM TAB. 100mg, MARZULENE-S GRANULES(India)
2002EPINASTINE TAB. 20mg「KT」
2003MARZULENE COMBINATION TAB. 1.0ES
2004AZULOXA GRANULES 2.5%(Korea)
2005KINALDOSE TAB. 50mg
2006KIRIGAMIL NASAL SOLUTION 50µg 28 MISTS
2007CETIRIZINE HYDROCHLORIDE TAB. 5mg/10mg「KTB」, MENATETRENONE CAP. 15mg「KTB」
2008MARZULENE COMBINATION TAB. 0.5ES
2009EPINASTINE TAB. 10mg「KT」, KORTRYTHM TAB. 50mg, REBAMIPIDE TAB. 100mg「KTB」, TEMOCAPRIL HYDROCHLORIDE TAB. 1mg/2mg/4mg「KTB」, MARZULENE COMBINATION TAB. 0.375 ES
2010SARPOGRELATE HYDROCHLORIDE TAB. 50mg/100mg「KTB」, GLIMEPIRIDE TAB. 1mg/3mg「KO」, FENOFIBRATE CAP 67mg/100mg「KTB」, PORATILE 1mg TAB.
2011AZULOXA TAB. 15mg, KIRIGAMIL NASAL SOLUTION 50µg 56 MISTS, DONEPEZIL HYDROCHLORIDE OD TAB. 3mg/5mg「KO」
2012PAROXETINE TAB. 10mg/20mg「KO」, PIOGLITAZONE TAB. 15mg/30mg「KO」, OLOPATADINE HYDROCHLORIDE TAB. 2.5mg/5mg「KO」, MOSAPRIDE CITRATE TAB. 2.5mg/5mg「KO」
2013PAROXETINE TAB. 5mg「KO」, PRAMIPEXOLE HYDROCHLORIDE TAB. 0.125mg/0.5mg「KO」, DONEPEZIL HYDROCHLORIDE OD TAB. 10mg「KO」, PITAVASTATIN CALCIUM TAB. 1mg/2mg「KO」
2014SUGLAT TAB. 25mg/50mg, CILOSTAZOL OD TAB. 50mg/100mg「KO」, PITAVASTATIN CALCIUM TAB. 4mg「KO」, LOSARHYD COMBINATION TAB. LD「KO」, CANDESARTAN TAB. 2mg/4mg/8mg/12mg「KO」
2015CLOPIDOGREL TAB. 25mg/75mg「KO」
2016LOSARHYD COMBINATION TAB. HD「KO」, MONTELUKAST TAB. 5mg/10mg「KO」
2017TORASEMIDE TAB. 4mg/8mg「KO」
2018SUJANU COMBINATION TAB., XOSPATA TAB. 40mg, FLECAINIDE ACETATE TAB. 50mg/100mg「KO」, RAMATROBAN TAB. 50mg/75mg「KO」, LORNOXICAM TAB. 2mg/4mg「KO」
2019ZONISAMIDE TAB. 100mg EX「KO」
2020Naratriptan Tablets 2.5mg「KO」
2022Tramadol Hydrochloride OD Tablets 25mg/50mg「KO」
2024Zonisamide OD Tablets 25mg/50mgTRE「KO」