Kotobuki's History

1949	Establishment of Kotobuki Pharmaceutical Started to sell herbal medicines which are extracted from herbs that are mainly produced in Nagano Prefecture
1965	Start to develop of synthetic active pharmaceutical ingredients focused particularly on research on manufacturing imported active pharmaceutical ingredients domestically
1968	Launched Gastritis, Gastric ulcer, duodenal ulcer therapeutic agent MARZULENE-S GRANULES in Japan
1978	Completion of pharmacy plant based on GMP (Good Manufacturing Practice) Completion of the first stage construction of Research Laboratory
1987	Completion of the second stage construction of Research Laboratory This leads to a start of full-scale development of new pharmaceuticals
1989	Completion of research facilities of Radio Isotope
1990	Launched Gastritis, Gastric ulcer, duodenal ulcer therapeutic agent MARZULENE-S GRANULES in China
1993	Completion of the second pharmacy plant based on GMP
2000	Launched Gastritis, Gastric ulcer, duodenal ulcer therapeutic agent MARZULENE-S GRANULES in India
2001	Launched new Gastric ulcer therapeutic agent AZULOXA GRANULES (Egualen Sodium) in Japan
2003	Launched Gastritis, Gastric ulcer, duodenal ulcer therapeutic agent MARZULEN ES TABLETS (Dosage form addition)
2004	Launched Gastric ulcer therapeutic agent AZULOXA GRANULES in South Korea Conformed to the inspection for compliance with the GCP (Good Clinical Practice)carried out by PMDA (Pharmaceuticals and Medical Devices Agency)
2005	Conformed to the inspection on synthesized drug substances carried out by foreign country regulatory authority
2006	Conformed to the inspection on AZULOXA GRANULES for compliance with the GPMSP (Good Post-Marketing Surveillance Practice) carried out by PMDA
2008	Launched Gastritis, Gastric ulcer, duodenal ulcer therapeutic agent MARZULEN COMBINATION TABLETS 0.5ES (Dosage form addition)
2009	Launched Gastritis, Gastric ulcer, duodenal ulcer therapeutic agent MARZULEN COMBINATION TABLETS 0.375ES (Dosage form addition)
2010	We performed an invitation lecture of KT6-971 by a medicinal chemistry sectional meeting of Americanization society(ACS)
2011	Gastric ulcer therapeutic agent AZULOXA TABLETS 15mg in Japan